How Cannabis and Coffee Work Together: Benefits and Effects

Published: 7/14/2025
How Cannabis and Coffee Work Together: Benefits and Effects

Coffee is more than a beverage, thanks to its ability to boost energy levels, awaken the mind, and fine-tune focus. For many, it's an essential morning ritual. The ever-growing list of cannabis-infused drinks and food also features coffee, often touted as a magical elixir. 

Since both cannabis and coffee influence the same region of the brain, you might be wondering: What happens when you mix weed with coffee? Does coffee ruin high or interact synergistically or antagonistically with cannabinoids? In this article, we’ll explore how cannabis and coffee work together. 

What happens when you consume cannabis and coffee together?

The active stimulant found in coffee is caffeine, which blocks adenosine receptors in the brain. As a result, it increases alertness, concentration, and energy levels while reducing drowsiness. 

On the other hand, the effects of cannabis depend on its primary cannabinoids like THC and CBD.  Like caffeine, THC is also a psychoactive compound, while CBD is non-psychoactive and known for its anti-inflammatory and therapeutic properties. 

THC binds to receptors in your ECS system (endocannabinoid system), particularly the CB1 receptors in the brain, and affects short-term memory and alters mood and cognition. 

Combining weed and caffeine can either enhance or counteract the psychoactive and stimulant effects of both substances. However, the immediate effects of consuming cannabis and coffee together may vary between individuals and depend on:

  • Individual response to cannabis and caffeine
  • How much you consume
  • Terpenes and cannabinoids found in cannabis
  • Since cannabis can cause inhibition and caffeine acts as a stimulant, cannabis can increase or decrease the stimulant effects of caffeine depending on your dose. 

    However, studies that evaluate the combined effects of coffee and cannabis are lacking. In an older preclinical study on rats, researchers found that combining both substances boosts energy, calms brain activity, enhances positive feelings, and helps with learning.

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    Effects and benefits of mixing cannabis and coffee:

    Cannabis-infused coffee provides many unique benefits. Some anecdotal evidence shows that caffeine enhances the benefits of a psychoactive compound of cannabis, THC. 

    With THC

  • Both substances are also responsible for increasing productivity and alertness. 
  • Some anecdotal studies also suggest that they both help combat fatigue. 
  • With CBD

    What cannabis product to use to make Cannabis-Infused Coffee?

    There are a variety of weed products that you can use to brew a cannabis-infused coffee:

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    Practical tips for combining coffee and cannabis

    Discover weed strains that complement your coffee at Smokeland!

    Want to elevate your brew for your special wake-and-bake morning? All it takes is choosing the right weed strain or weed products. Browse our carefully curated selection of cannabis products and strains that pair well with your morning coffee. Shop now with same-day weed delivery in California!

    How Cannabis and Coffee Work Together: Benefits and Effects